Chronic autoimmune processes play a role in the pathology of rheumatoid arthritis, leading to persistent joint inflammation and progressive bone destruction. Matrix metalloproteinases (MMPs) belong to the family of zinc-containing enzymes and play an important role in the degradation and remodelling of the extracellular matrix (ECM). MMPs are involved in cell proliferation, migration, inflammation and cellular metabolic processes. In recent decades, significant progress has been made in the availability of therapies and validated disease-monitoring scales, as well as in terms of clinical guidelines and the treat-to-target strategy. Joint damage is irreversible, so early and effective treatment is of paramount importance. Clinical guidelines aim for remission, or at least low disease activity.
MMP-3 is involved in connective tissue remodelling and is responsible for initiating MMP-mediated degradation processes. MMP-3 is a member of the matrix metalloproteinase family and plays an important role in the degradation of the extracellular matrix (e.g. matrix proteins, growth factors, proteases, surface receptors and adhesion molecules).
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For diagnosis or to monitor therapeutic response, results must always be interpreted in conjunction with the patient’s medical history, clinical examinations and other findings!
In Hungary, MMP-3 level testing is available nationwide on a self-funded basis through the SYNLAB blood collection network and at all private healthcare providers contracted with SYNLAB.
In other European countries, MMP-3 will be available soon.